Smart composites based on magnetic nanoparticles and responsive polymers

Smart Magnetic Composites

Smart polymers for responsive drug-delivery systems.

The rapid advancement of biomedical research has led to many creative applications for biocompatible polymers. As modern medicine discerns more mechanisms, both of physiology and of pathophysiology, the approach to healing is to mimic, or if possible, to recreate the physiology of healthy functioning. Thus, the area of smart polymers for responsive drug delivery has evolved. The developments fa...

Smart Nanoparticles Based on Hyaluronic Acid for Redox-Responsive and CD44 Receptor-Mediated Targeting of Tumor

BACKGROUND Since aggressive cancer cells highly express the CD44 receptor compared to normal cells, hyaluronic acid (HA) can be used for CD44 targeting molecule. Since glutathione (GSH) level is normally elevated in the intracellular compartment and in the tumor cell, the fact that disulfide bond can be cleaved by GSH is widely used for intracellular drug delivery. METHODS HA was connected wi...

Surface plasmon resonance biosensing based on target-responsive mobility switch of magnetic nanoparticles under magnetic fields

A novel surface plasmon resonance (SPR) detection technique based on the programmed assembly of superparamagnetic iron oxide nanoparticles (SPIONs) and the corresponding change in mobility under external magnetic fields was demonstrated. In this approach, SPIONs act as a magnetophoretic mobility switch undergoing aggregation only in the presence of target analytes. The aggregated SPIONs which w...

Hybrid Nanocomposite Based on CoFe2O4 Magnetic Nanoparticles and Polyaniline

CoFe2O4 Magnetic Nano Particles (MNPs) were synthesized by an efficient method in aqueous medium with the particle sizes of about 20-50 nm. Then, a hybrid nanocomposite of polyaniline (PANI)-CoFe2O4 MNPs has been electrodeposited directly on a stainless steel wire by the potentiostatic method. Microscopic images of electrodeposited PANI and PANI-C...